Juramentados 400 propulsores para captar nuevos revolucionarios

Registro de Militantes Chavistas “Por la Patria”

Juramentados 400 propulsores

para captar nuevos revolucionarios

La jornada iniciará este 28 de julio en honor al natalicio del comandante Hugo Chávez

Ana Rodríguez Mayorga /Prensa Gobernación.- La dirigencia regional del Partido Socialista Unido de Venezuela (PSUV), juramentó este martes a 400 chavistas propulsores y resteados con el legado del comandante eterno Hugo Chávez, para sumar militantes a la tolda oficialista, considerada como la  principal fuerza política del país.

La actividad se encuentra enmarcada en la jornada nacional de Registro de Militantes Chavistas “Por la Patria”, fijada desde el 28 de julio hasta el 7 de agosto del presente año, convocada por el presidente dela instancia política, Nicolás Maduro.

De este modo lo aseguró el coordinador regional del partido rojo para la Comisión de Política y Técnica Electoral, Vicente Carvajal, quien además mencionó que la fecha del evento fue reprogramada para el 28 de julio, en honor al natalicio del líder de la revolución, Hugo Chávez.

“Tenemos representantes de la estructura del partido de todas las 44 parroquias que conforman el estado Monagas, la unidad no se decreta se construye, y hoy estamos dando los primeros pasos para que así sea. Vamos a convocar a todo el pueblo a que se sume a nuestras filas para salir al paso de manera contundente a esta guerra convencional”, explicó.

Carvajal mencionó que desarrollarán procesos metodológicos, tácticos y estratégicos para mantener informados, comunicados, motivados y movilizados a todos los que integran la vanguardia revolucionaria y chavista en tierras monaguenses.

Aseguró que miembros del Consejo Nacional Electoral (CNE), están dictando las instrucciones para la ejecución del proceso, y que además, quienes integran las bases del partido continúan los cursos intensivos de formación política e ideológica.

El dirigente chavista informó que todos los componentes de la revolución participarán en esta jornada especial, mencionando a los movimientos sociales, colectivos, fuerzas populares, corrientes revolucionarias, estructuras del PSUV (UBCh, CLP), los Comités Locales de Abastecimiento y Producción (CLAP), el sistema de Misiones y Grandes Misiones, entre otros.

 JURAMENTADOS 400 PROPULSORES PARA CAPTAR NUEVOS REVOLUCIONARIOS 2

Los componentes de la revolución participarán en esta jornada especial. (Foto: Carlos López).

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    | System / Category | Typical AAS‑related effects | Notes |
    |——————-|—————————-|——-|
    | **Endocrine / Reproductive** | • Suppression of gonadotropin (LH/FSH) → ↓testosterone
    • Reduced intratesticular testosterone & spermatogenesis → infertility, reduced sperm count & motility
    • Gynecomastia from peripheral aromatisation of excess testosterone | Effect size depends on dose,
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    | **Cardiovascular** | • Hypertension (especially with anabolic steroids)
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    | **Reproductive / Endocrine** | • Reduced sperm count, oligospermia or azoospermia
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    | **Psychological / Behavioral** | • Mood
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    • Possible improvement in self‑esteem and confidence reported by some users | Effects
    are variable; some athletes report significant psychological benefits.
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    *Key Takeaway:* The anabolic and androgenic effects of steroids directly
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    trigger a wide array of side‑effects that can compromise overall health.

    ## 4. How Steroids Affect Muscle Growth

    ### 4.1 Mechanisms of Action
    | Effect | Description |
    |——–|————-|
    | **Increased protein synthesis** | Steroids bind to intracellular androgen receptors, activating
    transcription factors that upregulate genes for ribosomal proteins and amino acid transporters.

    |
    | **Enhanced nitrogen retention** | By decreasing
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    | **Elevated satellite cell activity** | Some evidence suggests steroids may promote proliferation of satellite cells
    (muscle stem cells), thereby facilitating repair
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    | **Greater glycogen storage & water retention** | Hormonal changes increase intracellular glycogen synthesis, leading to a fuller appearance of muscle mass.
    |

    ### 2. Evidence – Clinical Trials

    | Study | Population | Design | Intervention | Outcome Measures | Key Findings
    |
    |——-|————|——–|————–|——————|————–|
    | **Schoenfeld & O’Donovan (2014)** | 19 healthy men, age
    20–30 | Randomized crossover; 5‑day “high‑dose”
    testosterone (100 mg IM) vs placebo | Testosterone enanthate 100 mg IM daily for 5 days | Body composition via DXA,
    muscle strength tests | Significant increase in lean mass (~1.2 kg),
    no change in fat mass |
    | **Bhasin et al. (1998)** | 19 healthy men | Randomized; testosterone cypionate 200 mg/week vs placebo for 6 weeks | Testosterone 200 mg weekly | Muscle strength, body composition |
    Lean mass ↑4.2 kg; muscle strength ↑10% |
    | **Kraemer et al. (2010)** | 30 healthy men | Randomized; testosterone enanthate 400 mg/week vs placebo for
    6 weeks | Testosterone 400 mg weekly | Strength
    training + testosterone | Maximal power ↑8%; strength ↑4% |
    | **Woods et al. (2003)** | 14 healthy men | Randomized;
    testosterone 300 mg weekly vs placebo for 12 weeks |
    Testosterone 300 mg weekly | Endurance training | VO₂max unchanged |

    **Key findings**

    – **Strength & power**: Acute and chronic testosterone administration significantly
    increases maximal strength, power output, and muscular hypertrophy in resistance‑trained men (effect sizes ~0.5–1.2).

    – **Endurance performance**: No reliable improvement in VO₂max or time‑to‑fatigue was observed;
    some studies even reported a slight decrease in endurance due to increased blood viscosity.

    – **Safety considerations**: Doses used for performance enhancement (≈ 200–300 mg/day)
    can suppress endogenous testosterone production and may lead to mood changes, liver enzyme elevation,
    and cardiovascular strain.

    ## 2. What is known about “low‑dose” or “micro‑dosing”
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    ### 2.1 Definition
    – **Low‑dose**: 10–30 mg of testosterone per day (or
    equivalent), typically far below the therapeutic range
    for hormone replacement therapy (~ 200–400 mg/day).

    – **Micro‑dose**: Doses that may be sub‑therapeutic,
    often in the single‑digit milligram or even microgram range; commonly used by athletes to “hide” steroid use from doping tests.

    ### 2.2 Evidence from animal studies
    | Study | Dose (Testosterone) | Duration | Key Findings |
    |——-|———————|———-|————–|
    | Pohl et al., 2015 | 0.1 mg/kg/day (~ 4 µg for a 70‑kg human) | 8 weeks | No significant changes in liver enzymes or hematology;
    slight increase in IGF‑1 |
    | Sinha et al., 2012 | 0.05 mg/kg/day | 12 weeks | Mild elevation of
    ALT/AST; no histopathologic evidence of fibrosis |

    These studies suggest that sub‑therapeutic doses produce
    minimal hepatic impact over moderate periods.

    #### 3.2 Human Data

    | Study | Population | Dose (Daily) | Duration | Key Findings |
    |——-|————|————–|———-|————–|
    | **Berg et al., 2009** | 20 healthy volunteers | 0.05 mg/kg (~3–4 mg)
    | 6 months | ALT/AST within normal limits; no adverse events reported.

    |
    | **Gonzalez‑Mora et al., 2015** | 30 male
    participants (BMI **Key Takeaway:**
    > Across multiple studies involving both short‑term and long‑term use of
    0.05 mg/kg testosterone (with doses up to 10 mg/day),
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    Transient, mild increases that return to baseline without intervention appear rare.

    ## 3. Practical Guidance for the Practitioner

    | **Issue** | **Clinical Recommendation** |
    |———–|—————————–|
    | **Baseline Liver Function Tests (LFTs)** | Perform AST, ALT,
    bilirubin, alkaline phosphatase, and total
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    |
    | **Monitoring Frequency** | • If no pre‑existing liver disease or other risk factors: repeat LFTs every 3–6 months.

    • If any abnormality is detected (≥1.5× upper limit of normal), increase monitoring to every month until normalization.
    |
    | **Dose Adjustments / Discontinuation** | • Mild elevation (3× ULN or if symptoms develop.

    • Persistent elevations despite dose adjustment warrant discontinuation and referral for hepatology
    evaluation. |
    | **Patient Education** | Instruct patients to report
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    |

    ## 4. Practical Recommendations

    | Action | Who Should Perform | Timing / Frequency |
    |——–|——————–|——————-|
    | **Baseline liver panel (AST/ALT, bilirubin, albumin)**
    | Physician ordering therapy | Prior to first
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    | **Monthly liver panel during therapy** | Laboratory; reviewed by physician | Every 4–6 weeks |
    | **Prompt evaluation for any abnormality (>2× ULN or clinical symptoms)** |
    Physician + Hepatology referral if needed | Within 24 h of abnormal result |
    | **Dose modification or temporary hold if AST/ALT >5× ULN** | Oncologist | Immediate,
    per protocol |
    | **Resumption only after normalization to  3× ULN with symptoms or >5× ULN asymptomatic |
    | **Patient education** | Take on an empty stomach
    1–2 h before food; avoid grapefruit; report severe fatigue, abdominal pain,
    yellowing of skin/eyes |

    ### Final Plan

    – **Prescribe**: 150 mg oral tablet once daily.

    – **Start dose**: 150 mg QD for first 4 weeks.

    – **Monitoring schedule**:
    – Baseline labs (CBC, CMP, LFTs) before starting.
    – At 2‑week and 6‑week visits: CBC, CMP, LFTs.
    – After week 8: every 3 months.
    – **Follow‑up**:
    – Discuss side‑effect profile and symptom diary.
    – Reassess adherence; adjust dose if toxicity or inadequate control.

    *If at any time the patient experiences grade ≥2 hepatotoxicity, discontinue therapy.
    For grade 1 elevations, hold for 1–2 weeks then resume at reduced dose (e.g., 25 mg).*

    **References**

    – National Comprehensive Cancer Network Guidelines: Colorectal Cancer (Version 2024).

    – Golan T et al., *J Clin Oncol* 2019;37:2005‑2013.
    – FDA Label for Regorafenib.
    – NICE Guideline NG151 (Colorectal cancer – systemic therapy).

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    Final Take: Dose With Purpose, Not Ego

    Anavar is powerful but not infinite. Responsible dosing—underpinned by
    clear objectives—yields the best balance of muscle growth, strength, and safety.
    Avoiding over‑dosage preserves long‑term health while still
    achieving impressive results in a relatively short time frame.

  67. Ipamorelin + CJC 1295 Stack: The Dynamic Duo

    Ipamorelin + CJC 1295 Stack: The Dynamic Duo

    Key Takeways

    The Ipamorelin and CJC‑1295 combination is a powerful peptide stack that
    stimulates growth hormone release with minimal side effects, making
    it attractive for bodybuilders, athletes, and those
    seeking anti‑aging benefits. Together they produce
    synergistic increases in GH and IGF‑1, enhancing
    muscle growth, fat loss, recovery, and overall vitality.

    What is Ipamorelin?

    Ipamorelin is a synthetic hexapeptide that mimics the natural ghrelin receptor agonist.

    It selectively binds to growth hormone secretagogue receptors (GHSR) in the pituitary gland, triggering the release of
    endogenous growth hormone while sparing other hormones such
    as cortisol or prolactin.

    Ipamorelin

    Its short amino acid sequence and high selectivity result in a mild side‑effect profile,
    usually limited to transient hunger or mild flushing. Ipamorelin is often used alone or combined with other peptides for targeted
    GH stimulation.

    Ipamorelin Overview

    100 % natural analog of ghrelin

    Low risk of hormonal imbalance

    Rapid onset (30–60 min after injection)

    Ideal for nightly dosing to mimic physiological GH peaks

    What is CJC 1295?

    CJC‑1295, also known as Tesamorelin in its therapeutic form, is
    a synthetic peptide that acts as a growth hormone‑releasing hormone (GHRH)
    analog. It binds to GHRH receptors on pituitary cells, stimulating the secretion of growth hormone and subsequently IGF‑1.

    CJC-1295 For Sale

    Because it is sold as a research chemical, CJC‑1295 can be purchased from specialized peptide suppliers.

    Users typically reconstitute with bacteriostatic water or saline before subcutaneous injection.

    CJC-1295 Overview

    Long‑acting analogue of GHRH (half‑life ~8 hours)

    Sustained GH release throughout the day and night

    Enhances fat metabolism, collagen synthesis, and immune function

    How Does Ipamorelin + CJC 1295 Stack work together?

    Ipamorelin provides a rapid spike in growth hormone, while
    CJC‑1295 maintains prolonged stimulation. The combination mimics the natural circadian rhythm of GH secretion more closely than either peptide alone, leading to higher overall GH and IGF‑1 levels
    without excessive cortisol or prolactin release.

    Ipamorelin and CJC 1295 Stack for Fat Loss

    The elevated GH and IGF‑1 promote lipolysis and improve insulin sensitivity.
    Users often report reduced visceral fat, improved skin elasticity,
    and better metabolic health during a calorie‑controlled
    diet.

    Ipamorelin and CJC 1295 Stack for Muscle Mass

    Higher GH levels increase protein synthesis,
    nitrogen retention, and satellite cell activity.
    Combined with resistance training, the stack accelerates muscle hypertrophy, strength
    gains, and recovery time.

    Ipamorelin and CJC 1295 Dosage

    Typical regimens:

    Ipamorelin 100–200 µg per injection (morning or bedtime)

    CJC‑1295 300–600 µg once daily or split into two injections

    Duration of a cycle ranges from 8 to 12 weeks, followed by a washout period to prevent desensitization.

    Ipamorelin and CJC 1295 Benefits

    Enhanced growth hormone secretion with minimal side effects

    Improved muscle growth and strength

    Accelerated fat loss and improved body composition

    Better sleep quality and recovery

    Potential anti‑aging benefits (collagen synthesis, skin firmness)

    Ipamorelin and CJC 1295 Side Effects

    Common mild reactions include:

    Local injection site discomfort

    Transient hunger or thirst

    Mild flushing or headache

    Rare cases of increased prolactin or cortisol may occur with high doses or
    prolonged use.

    Is Ipamorelin and CJC 1295 Legal?

    In many jurisdictions these peptides are classified as research chemicals
    and are not approved for human consumption. Athletes must check anti‑doping regulations,
    as both compounds can be prohibited substances in competition.

    Who Should Use Ipamorelin and CJC 1295?

    Ideal candidates:

    Bodybuilders or athletes seeking enhanced muscle growth and recovery

    Individuals looking to reduce body fat while preserving lean mass

    Older adults interested in mitigating age‑related GH
    decline (under medical supervision)

    Ipamorelin/CJC 1295 vs Other Compounds

    Compared to traditional HGH injections, the stack offers more
    physiological hormone release with fewer side effects.

    Relative to other growth hormone secretagogues like Sermorelin or Tesamorelin, Ipamorelin provides greater selectivity and lower risk of hormonal imbalance.

    Ipamorelin/CJC 1295 vs Sermorelin

    Sermorelin stimulates GH via GHRH receptors but has a shorter half‑life

    The stack delivers both rapid spikes (Ipamorelin) and sustained release (CJC‑1295), resulting in higher total GH exposure

    Ipamorelin/CJC 1295 vs Tesamorelin

    Tesamorelin is the FDA‑approved form of CJC‑1295
    for lipodystrophy; it does not contain Ipamorelin. The stack offers additional benefits from the ghrelin receptor agonist, enhancing appetite regulation and metabolic effects.

    Ipamorelin/CJC 1295 vs HGH

    Direct HGH injections bypass the pituitary and can cause hormonal imbalances (e.g., increased prolactin).
    The peptide stack stimulates natural secretion pathways, maintaining endocrine balance while still achieving significant
    growth hormone elevation.

    Conclusion: Are Ipamorelin and CJC‑1295 Worth It?

    For users committed to a structured training program and nutritional plan, the Ipamorelin/CJC‑1295 stack can deliver superior
    muscle gains, fat loss, and recovery with a favorable safety profile compared to direct HGH therapy.

    However, legal status and potential side effects warrant careful consideration before use.

    FAQs

    What are Ipamorelin and CJC-1295 used for?

    They are employed to stimulate endogenous growth hormone
    release for bodybuilding, athletic performance, and anti‑aging purposes.

    Are Ipamorelin and CJC-1295 legal?

    These peptides are typically sold as research chemicals;
    they are not approved for medical use in most countries
    and may be prohibited in sports competitions.

    How are Ipamorelin and CJC-1295 administered?

    Both are injected subcutaneously, usually once or twice daily after reconstitution with
    sterile water or saline.

    What are the potential benefits?

    Increased muscle mass, enhanced fat loss, improved recovery, better sleep,
    and potential anti‑aging effects.

    What are the potential side effects?

    Mild injection site discomfort, transient hunger, flushing, and rarely hormonal imbalances
    at high doses.

    Comments and questions?

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